Tert-butyl 5-((4-(3-(4-fluorophenylamino)prop-1-ynyl)phenyl)-ethynyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate → tert-Butyl-5-(4-(3-(4-fluorophenylamino)propyl)phenethyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate

Participants

Reaction Steps

When the product of Step B was substituted for tert-butyl-5-((4-(N-(6,6-dimethylbicyclo[3.1.1]heptan-2-yl)sulfamoyl)phenyl-)ethynyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate in Example 19, Step C, the similar process afforded the title compound in 94% yield, as creamy gum. 1H-NMR (CDCl3) 1.42 (s, 3H); 1.44 (s, 3H); 1.46 (s, 9H); 1.87-1.96 (m, 4H); 2.5-2.56 (m, 2H); 2.67 (tr, 2H, J=7.32 Hz); 3.04 (tr, 2H, J=7.05 Hz); 3.86 (d, 2H, J=11.8 Hz); 3.88 (d, 2H, J=11.7 Hz); 4.9 (s, 1H); 6.45-6.50 (m, 2H); 6.82-6.88 (m, 2H); 7.09 (s, 4H).

Provenance & Evidence