tert-Butyl-5-(4-(6-methoxy-3-(3,4,5-trimethoxybenzoyl)-1H-indol-1-ylsulfonyl)phenethyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate → 2-Amino-2-(3-(3,4,5-trimethoxyphenethyl)phenethyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step C was substituted for tert-butyl-5-(4-(6-methoxy-3-(3,4,5-trimethoxybenzoyl)-1H-indol-1-ylsulfonyl)-phenethyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate in Example 13, Step F, the similar process afforded the title compound in 74% yield, as colourless solid. 1H-NMR (CDCl3) 1.7-1.8 (m, 2H); 2.51-2.52 (m, 2H); 2.77 (s, 4H); 3.31-3.42 (m, 13H); 6.26 (s, 2H); 6.81 (s, 1H); 6.95-6.97 (m, 2H); 7.13 (tr, 1H, J=7.44 Hz).

Provenance & Evidence