1-Octyne → HCID 131733952, compound

Participants

Reaction Steps

When tert-butyl-5-ethynyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate was substituted for 1-octyne and the product of Step A was substituted for 5-iodo-2-tritylisoindoline in Example 2, Step D, the similar process afforded the title compound in 62% yield, as pale paste. 1H-NMR (CDCl3) 1.46 (s, 3H); 1.48 (s, 9H); 1.50 (s, 3H); 1.47-2.14 (m, 16H); 3.94-4.11 (m, 4H); 4.72 (5, 2H); 5.19 (s, 1H); 6.87 (d, 2H, J=8.85 Hz); 7.33 (d, 2H, J=8.79 Hz).

Provenance & Evidence