1-Octyne → HCID 131733954, compound

Participants

Reaction Steps

When tert-butyl-5-ethynyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate was substituted for 1-octyne and the product of Step A was substituted for 5-iodo-2-tritylisoindoline in Example 2, Step D, the similar process afforded the title compound in 35% yield, as pale paste. 1H-NMR (CDCl3) 1.47 (s, 3H); 1.48 (s, 9H); 1.5 (s, 3H); 1.77 (broad s, 6H); 2.07 (broad s, 3H); 2.12 (s, 6H); 3.86 (s, 3H); 4.00 (d, 2H, J=11.38 Hz); 4.10 (d, 2H, J=11.45 Hz); 5.20 (s, 1H); 6.9 (d, 1H, J=8.46 Hz); 7.28-7.5 (s, 6H).

Provenance & Evidence