Tetrahydrofuran → HCID 66726561, compound

Participants

Reaction Steps

The suspension of the product of Step C (0.13 g; 0.293 mmol) and 1 M TBAF in THF (0.3 ml; 0.3 mmol) in anhydrous toluene (5 ml) was refluxed for 1 h under N2, cooled to room temperature and evaporated to dryness under reduced pressure. The residue was purified by FCC (SiO2; CH2Cl2) to give the title compound (0.12 g; 99%) as a colourless solid. 1H-NMR (CDCl3) 1.78 (s, 6H); 2.01-2.16 (m, 9H); 3.96 (s, 3H); 6.66 (m, 1H); 6.98 (d, 1H, J=8.6 Hz); 7.26 (m, 1H); 7.36 (d, 1H, J=8.14 Hz); 7.48 (d, 1H, J=8.14 Hz); 7.68 (d, 1H, J=1.6 Hz; 7.77 (dd, 1H, J=1.6, 8.1 Hz); 8.01 (dd, 1H, J=1.6, 8.1 Hz); 8.32 (broad s, 1H); 8.51 (s, 1H).

Provenance & Evidence