tert-Butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step D was substituted for tea-butyl 2,2-dimethyl-5-((4-octylphenylamino)methyl)-1,3-dioxan-5-ylcarbamate in Example 1, Step B, the identical process afforded the title compound in 71% yield, as a creamy solid. 1H-NMR (CDCl3) 1.5 (m, 6H); 1.82 (broad s, 4H+H2O); 3.16 (m, 2H); 3.41-3.59 (m, 8H); 4.13-4.3 (m, 4H); 6.96 (d, 1H, J=7.9 Hz); 7.2 (tr, 1H, J=7.9 Hz); 7.5 (d, 1H, 7.8 Hz); 7.67 (d, 1H, J=1.9 Hz); 7.7 (dd, 1H, J=1.9, 8.4 Hz).

Provenance & Evidence