tert-Butyl 2,2-dimethyl-5-((4-octylphenylamino)methyl)-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((4-(5-(2'-(trifluoromethyl)biphenyl-4-yl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step E was substituted for tert-butyl 2,2-dimethyl-5-((4-octylphenylamino)methyl)-1,3-dioxan-5-ylcarbamate in Example 1, Step B, the identical process afforded the title compound in 71% yield, as a creamy solid. 1H-NMR (CD3OD+CDCl3) 3.1 (s, 2H); 3.35-3.6 (m, 8H); 4.1 (HDO); 6.76 (d, 1H, J=7.8 Hz); 7.17 (tr, 1H, J=7.8 Hz); 7.33 (tr, 1H, J=7.5 Hz); 7.41-7.51 (m, 4H); 7.57 (tr, 1H, J=7.3 Hz); 8.19 (d, 2H, J=8.3 Hz).

Provenance & Evidence