Hydrochloric Acid → HCID 16772687, compound

Participants

Reaction Steps

A solution of the product of Step B (0.29 g; 1.0 mmol), 36% HCl (0.16 ml) and 10% Pd/C (0.17 g) in EtOH (15 ml) was stirred for 3 h at 0° C. under H2 (balloon). The catalyst was removed by filtration through Celite pad, washed with EtOH (2×10 ml) and combined filtrates were evaporated to dryness under reduced pressure and the dark residue was diluted to 10 ml with CH3CN and the white precipitate was filtered off, washed with fresh CH3CN (2 ml) and dried to give the title compound (0.2 g; 70%) as off white solid. 1H-NMR (D2O) (2.86 (tr, 2H, J=7.2 Hz); 3.15 (tr, 2H, J=7.2 Hz); 4.66 (HDO); 5.07 (s, 2H); 6.85-6.89 (m, 3H); 7.02 (m, 1H); 7.11-7.34 (m, 4H).

Provenance & Evidence