tert-Butyl 2,2-dimethyl-5-((4-octylphenylamino)methyl)-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((6-((2'-(trifluoromethyl)biphenyl-4-yl)methoxy)-3,4-dihydroisoquinolin-2(1H)-yl)methyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step C was substituted for tert-butyl 2,2-dimethyl-5-((4-octylphenylamino)methyl)-1,3-dioxan-5-ylcarbamate in Example 1, Step B, the identical process afforded the title compound in 75% yield, as an off white solid. 1H-NMR (CDCl3+CD3OD) 2.5-3.9 (m, 16H+H2O); 5.02 (s, 2H); 6.69-6.91 (m, 3H); 7.25-7.53 (m, 7H); 7.68 (d, 1H, J=7.8 Hz).

Provenance & Evidence