Indoline-4-ol → tert-Butyl 5-((4-hydroxyindolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate

Participants

Reaction Steps

When the product of Step A was substituted for tert-butyl 5-((5-hydroxyindolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate in Example 8, Step G, the identical process afforded the title compound in 74% yield, as a creamy solid. 1H-NMR (CDCl3) 1.4-1.65 (m, 15H+H2O); 2.94 (tr, 2H, J=8.4 Hz); 3.5 (tr, 2H, J=8.4 Hz); 3.52 (s, 2H); 3.8-3.99 (m, 4H); 4.64 (broad s, 1H); 4.7 (broad s, 1H); 6.15-6.23 (m, 2H); 6.93 (tr, 1H, J=7.96 Hz).

Provenance & Evidence