5-(3,4-Diethoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole → 3-(Indolin-4-yl)-5-(2-methylbenzofuran-5-yl)-1,2,4-oxadiazole

Participants

Reaction Steps

When the product of Step D was substituted for 5-(3,4-diethoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole in Example 34, Step C, the identical process afforded the title compound in 100% yield, as a colourless foam. 1H-NMR (CDCl3) 2.49 (s, 3H); 2.52 (broad s, 1H+H2O); 3.48 (tr, 2H, J=8.44 Hz); 3.68 (tr, 2H, J=8.44 Hz); 6.48 (s, 1H); 6.85 (d, 1H, J=7.75 Hz); 7.2 (tr, 2H, J=7.6 Hz); 7.38 (d, 1H, J=8.16 Hz); 7.51 (d, 1H, J=8.5 Hz); 8.06 (d, 1H, J=8.5 Hz); 8.32 (s, 1H).

Provenance & Evidence