tert-Butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((4-(5-(3,4-di-propoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step E was substituted for tert-butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate in Example 34, Step E, the identical process afforded the title compound in 67% yield., as a colourless solid. 1H-NMR (DMSO-d6) 0.95-1.01 (m, 6H); 1.37 (s, 2H); 1.68-1.8 (m, 4H); 2.98 (s, 2H); 3.2-3.3 (m, 6H+H2O); 3.5-3.57 (m, 2H); 3.9-4.05 (m, 4H); 4.55 (broad s, 2H); 6.77 (d, 1H, J=9 Hz); 7.1-7.26 (m, 3H); 7.58 (d, 1H, J=3 Hz); 7.71 (dd, 1H, J=3, 9 Hz).

Provenance & Evidence