Propyl 3-iodo-4-propoxybenzoate → 3-Iodo-4-propoxybenzoic acid

HRID 710402Notes

Reaction equation

HRID 710402 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1[O:14][CH2:15][CH2:16][CH3:17])[C:5]([O:7]CCC)=[O:6].C(OC1C=C(C=CC=1OCCC)C(OCCC)=O)CC>>[I:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]=1[O:14][CH2:15][CH2:16][CH3:17])[C:5]([OH:7])=[O:6]

Participants

3

Reactant 2

HCID 66726335Propyl 3-iodo-4-propoxybenzoateHCID 66726576Propyl 3,4-dipropoxybenzoate

Product 1

HCID 448288973-Iodo-4-propoxybenzoic acid

Procedure

When the product of Step B was substituted for propyl 3,4-dipropoxybenzoate in Example 43, Step B, the identical process afforded the title compound in 94%, as creamy solid. 1H-NMR (CDCl3) 1.04-1.15 (m, 3H); 1.83-1.94 (m, 2H); 3.99-4.08 (m, 2H); 6.8 (d, 1H, J=6 Hz); 8.04 (dd, 1H, J=3, 6 Hz); 8.5 (d, 1H, J=3 Hz).

Sources & evidence

ORD record
ord-acd7f3164e7e4d619a4a8ce41c7e76ce
Source dataset
uspto-grants-2015_11
Patent number
US09181182B2

Reaction notes

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