tert-Butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((4-(5-(3-iodo-4-propoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step F was substituted for tert-butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate in Example 34, Step E, the identical process afforded the title compound in 75% yield., as a colourless solid. 1H-NMR (DMSO-d6) 1.02 (tr, 3H, J=7.3 Hz); 1.4 (broad s, 2H); 1.72-1.8 (m, 2H); 2.98 (s, 2H); 3.2-3.4 (m, 6H+H2O); 3.53 (tr, 2H, J=8.3 Hz); 4.09 3.53 (tr, 2H, J=6.1 Hz); 4.56 (broad s, 2H); 6.76 (d, 1H, J=7.7 Hz); 7.09-7.25 (m, 3H); 8.1 (d, 1H, J=8.8 Hz); 8.44 (s, 1H).

Provenance & Evidence