tert-Butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((4-(5-(3-amino-4-propoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step F was substituted for tert-butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate in Example 34, Step E, the identical process afforded the title compound in 70% yield, as a creamy solid. 1H-NMR (DMSO-d6) 0.92-1.05 (m, 3H); 1.42 (broad s, 2H); 1.7-1.81 (m, 2H); 2.99 (s, 2H); 2.42-2.51 (m, 2H); 2.95 (s, 2H); 3.11-3.4 (m, 2H, +H2O); 3.53 (tr, 2H, J=9 Hz); 3.93-4.05 (m, 2H); 4.56 (m, 2H); 5.11 (s, 2H); 6.76 (d, 1H, J=6 Hz); 6.97 (d, 1H, J=9 Hz); 7.0 (d, 1H, J=6 Hz); 7.1-7.25 (m, 2H); 7.32-7.42 (m, 2H).

Provenance & Evidence