tert-Butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((4-(5-(3,4-dipropylphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step F was substituted for tert-butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate in Example 34, Step E, the identical process afforded the title compound in 80% yield, as a creamy solid. 1H-NMR (DMSO-d6) 0.94-0.97 (m, 6H); 1.33 (s, 2H); 1.53-1.62 (m, 4H); 2.61-2.68 (m, 4H); 2.98 (s, 2H); 3.2-3.3 (m, 6H, +H2O); 3.54 (tr, 2H, J=9 Hz); 4.55 (m, 2H); 6.77 (d, 1H, J=6 Hz); 7.1-7.16 (m, 1H); 7.25 (d, 1H, J=6 Hz); 7.87-7.91 (m, 2H).

Provenance & Evidence