tert-Butyl 5-((4-(5-(4-propylphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate → HCID 46195603, compound

Participants

Reaction Steps

When the product of Step C was substituted for tea-butyl 5-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate in Example 34, Step E, the identical process afforded the title compound in 80% yield, as a creamy solid. 1H-NMR (DMSO-d6) 0.85-0.95 (m, 3H); 1.33 (broad s, 2H); 2.6-2.66 (m, 2H); 2.98 (s, 2H); 3.2-3.34 (m, 8H+H2O); 3.54 (tr, 2H, J=8.3 Hz); 4.56 (broad s, 2H); 6.77 (d, 1H, J=7.77 Hz); 7.1-7.26 (m, 2H); 7.38-7.49 (m, 2H); 7.9-8.1 (m, 2H).

Provenance & Evidence