5-(3,4-dipropoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole → 5-(3-Chloro-4-ethoxyphenyl)-3-(indolin-4-yl)-1,2,4-oxadiazole

Participants

Reaction Steps

When the product of Step B was substituted for 5-(3,4-dipropoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole in Example 43 Step D, the similar process afforded the title compound in 100% yield, as a creamy solid. 1H-NMR (CDCl3) 1.52 (tr, 3H, J=6.95 Hz); 3.69 (tr, 2H, J=7.53 Hz); 3.92 (tr, 2H, J=7.43 Hz); 4.18 (q, 2H, J=6.98 Hz); 7.03 (d, 1H, J=8.67 Hz); 7.39-7.45 (m, 2H), 7.94-8.10 (m, 2H), 8.21 (d, 1H, J=2.07 Hz).

Provenance & Evidence