3-Chloro-4-propoxybenzoic acid → 5-(3-chloro-4-propoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole

Participants

Reaction Steps

When the product of Step C was substituted for 5-(3,4-dipropoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole in Example 43 Step C, the similar process afforded the title compound in 35% yield, as off white solid. 1H-NMR (CDCl3) 1.1 (tr, 3H, J=7.37 Hz); 1.78-1.95 (m, 2H); 4.09 (t, 2H, J=6.47 Hz); 7.03 (d, 1H, J=8.66 Hz); 7.34-7.39 (m, 3H); 7.56 (d, 1H, J=8.14 Hz); 8.04 (d, 1H, J=6.8 Hz); 8.1 (dd, 1H, J=8.6, 2.1 Hz); 8.28 (d, 1H, J=3.21 Hz); 8.38 (broad s, 1H).

Provenance & Evidence