5-(3,4-Diethoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole → 5-(3-Chloro-4-propoxyphenyl)-3-(indolin-4-yl)-1,2,4-oxadiazole

Participants

Reaction Steps

When the product of Step D was substituted for 5-(3,4-diethoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole in Example 34, Step C, the identical process afforded the title compound in 99% yield. 1H-NMR (CDCl3) 1.09 (tr, 3H, J=7.37 Hz); 1.81-1.94 (m, 2H); 3.51 (tr, 2H, J=8.08 Hz); 3.71 (tr, 2H, J=8.48 Hz); 4.08 (tr, 2H, J=6.47 Hz); 6.92 (d, 1H, J=7.44 Hz); 7.00 (d, 1H, J=8.72 Hz); 7.22 (tr, 1H, J=7.85 Hz); 7.65 (d, 1H, J=7.78 Hz); 8.04 (dd, 1H, J=8.63, 2.11 Hz); 8.21 (d, 1H, J=2.09 Hz).

Provenance & Evidence