5-(3,4-Diethoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole → 5-(4-Butoxy-3-chlorophenyl)-3-(indolin-5-yl)-1,2,4-oxadiazole

Participants

Reaction Steps

When the product of Step C was substituted for 5-(3,4-diethoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole in Example 34, Step C, the identical process afforded the title compound in 92% yield. 1H-NMR CDCl3) 0.97 (tr, 3H, J=8.34 Hz), 1.41-1.6 (m, 2H); 1.76-1.91 (m, 2H); 3.45 (tr, 2H, J=8.16 Hz; 3.63 (tr, 2H); 4.10 (tr, 2H, J=6.45 Hz); 6.75 (d, 1H, J=7.56 Hz); 7.06 (d, 1H, J=7.11 Hz); 7.18 (tr, 1H, J=7.77 Hz); 7.51 (broad d, 1H, J=7.8 Hz); 8.04 (dd, 1H, J=2.07-8.61 Hz); 8.21 (d, 1H, J=2.07 Hz).

Provenance & Evidence