5-(3,4-Diethoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole → 5-(3-Chloro-4-(pentyloxy)phenyl)-3-(indolin-5-yl)-1,2,4-oxadiazole

Participants

Reaction Steps

When the product of Step C was substituted for 5-(3,4-diethoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole in Example 34, Step C, the identical process afforded the title compound in 100% yield. 1H-NMR (CDCl3) 0.94 (tr, 3H, J=7.11 Hz); 1.44-1.54 (m, 4H); 1.66-2.03 (m, 2H); 3.45 (tr, 2H, J=8.16 Hz); 3.65 (tr, 2H, J=7.83 Hz); 4.11 (tr, 2H, J=6.51 Hz); 6.75 (d, 1H, J=7.68 Hz); 7.00 (d, 1H, J=8.67 Hz); 7.20 (tr, 1H, J=6.24 Hz); 7.51 (broad d, 1H, J=7.77 Hz); 8.04 (dd, 1H, J=2.13, 8.64 Hz); 8.21 (d, 1H, J=2.1 Hz).

Provenance & Evidence