反应详情

A suspension of the product of Step B (0.25 g, 0.7 mmol) and 10% Pd/C (0.1 g) in EtOH (10 ml) was stirred overnight under H2. The mixture was filtered through Celite bead and the filtrate was evaporated to dryness to give the desired product (0.25 g, 98%) as pale paste. 1H-NMR (CDCl3) 2.97-3.1 (m, 4H); 6.5 (m, 1H); 7.04 (dd, 1H, J=1.37, 8.3 Hz), 7.15-7.2 (m, 2H); 7.30-7.34 (m, 2H); 7.37-7.44 (m, 2H); 7.51 (d, 1H, J=7.56 Hz); 8.68 (broad s, 1H).

1. filtrationThe mixture was filtered through Celite bead
2. customthe filtrate was evaporated to dryness