反应详情

When the product of Step A was substituted for 6-iodoindole and tert-butyl 5-ethynyl-2,2-dimethyl-1,3-dioxan-5-ylcarbamate was substituted for 4′-ethynyl-2-(trifluoromethyl) biphenyl in Example 59, Step B the identical process afforded the title compound in 48%, as creamy paste. 1H-NMR (CDCl3) 0.85 (tr, 3H, J=8.99 Hz); 1.27-1.47 (m, 23H); 1.73 (s, 6H); 1.8-1.87 (m, 2H); 2.06 (s, 9H); 3.94 (tr, 2H, J=6.34 Hz); 3.99 (d, 2H, J=11.44 Hz); 4.08 (d, 2H, J=11.52 Hz); 5.17 (s, 1H); 6.73 (d, 1H, J=8.41 Hz); 7.19-7.21 (m, 2H).