5-(3,4-Diethoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole → 3-(Indolin-4-yl)-5-(6-propylpyridin-3-yl)-1,2,4-oxadiazole

Participants

Reaction Steps

When the product of Step C was substituted for 5-(3,4-diethoxyphenyl)-3-(1H-indol-4-yl)-1,2,4-oxadiazole in Example 34, Step C, the similar process afforded the title compound in 19% yield, as creamy solid. 1H-NMR (CDCl3) 1.01 (m, 3H); 1.7-1.9 (m, 2H); 2.87 (m, 2H); 3.46 (tr, 2H, J=9 Hz); 3.64 (tr, 2H, J=9 Hz); 3.9 (broad s, 1H); 6.76 (d, 1H, J=6 Hz); 7.16 (m, 1H); 7.33 (d, 1H, J=9 Hz); 7.53 (dd, 1H, J=2, 9 Hz); 8.35 (dd, 1H, 3, 9 Hz); 9.33 (d, 1H, J=3 Hz).

Provenance & Evidence