4-Propylbenzoic acid → 5-(4-Propylphenyl)-3-(quinolin-5-yl)-1,2,4-oxadiazole

Participants

Reaction Steps

When the product of Step B was substituted for N-hydroxy-1H-indole-4-carboximidamide and 4-propylbenzoic acid was substituted for 6-propylnicotinic acid in Example 66, Step C, the similar process afforded the title compound in 36% yield, as creamy solid. 1H-NMR (CDCl3) 0.97 (tr, 3H, J=9 Hz); 1.7 (m, 2H); 2.69 (tr, 2H, J=9 Hz); 7.38 (d, 2H, J=9 Hz); 7.53 (d, 0.5H, J=6 Hz); 7.56 (d, 0.5H, J=6 Hz); 7.8-7.86 (m, 1H); 8.17 (d, 2H, J=9 Hz); 8.45 (m, 1H); 8.9 (dd, 1H, j=3, 6 Hz); 9.4 (d, 1H, J=9 Hz).

Provenance & Evidence