反应详情

A solution of the product of Step C (0.07 g; 0.21 mmol) and Cs2CO3 (0.07 g; 0.21 mmol) in MeOH (2 ml) was stirred overnight at room temperature under N2. After removing solvent under reduced pressure, the residue was diluted to 15 ml with Et2O, washed with H2O, brine, dried over anhydrous MgSO4, filtered and filtrate evaporated to dryness to give the title compound (0.045 g; 93%), as brownish oil, which was used in the next step without further purification. 1H-NMR (CDCl3) 0.86 (m, 3H); 1.28 (m, 10H); 2.47 (m, 2H); 2.95 (m, 2H); 3.52 (m, 2H); 3.7 (broad s, 1H); 6.47-6.54 (m, 2H); 6.89-7.02 (m, 1H).

1. customAfter removing solvent under reduced pressure
2. additionthe residue was diluted to 15 ml with Et2O
3. washwashed with H2O, brine
4. dry with materialdried over anhydrous MgSO4
5. filtrationfiltered
6. customfiltrate evaporated to dryness