tert-Butyl 2,2-dimethyl-5-((4-(5-(6-propylpyridin-3-yl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-1,3-dioxan-5-ylcarbamate → 2-Amino-2-((4-octylindolin-1-yl)methyl)propane-1,3-diol

Participants

Reaction Steps

When the product of Step E was substituted for tert-butyl 2,2-dimethyl-5-((4-(5-(6-propylpyridin-3-yl)-1,2,4-oxadiazol-3-yl)indolin-1-yl)methyl)-1,3-dioxan-5-ylcarbamate in Example 66, Step F, the identical process afforded the title compound in 68% yield, as colourless solid. 1H-NMR (CDCl3) 0.86 (m, 3H); 1.28 (m, 10H); 1.53 (m, 2H); 1.8 (broad s, 4H+H2O); 2.48 (tr, 2H, J=7.6 Hz); 2.93 (tr, 2H, J=8.2 Hz); 3.08 (s, 2H); 3.46 (tr, 2H, J=8.7 Hz); 3.58 (m, 4H); 6.46 (d, 1H, J=7.8 Hz); 6.53 (d, 1H, J=7.6 Hz); 7.01 (m, 1H).

Provenance & Evidence