Methanol → HCID 46195744, compound

Participants

Reaction Steps

To a solution of the product of Step A (0.0346 g; 0.0743 mmol) and NaI (0.033 g; 0.22 mmol) in anhydrous CH3CN (1 ml) Me3SiCl (0.1 ml) was added at room temperature under N2. After stirring for 30 min at room temperature MeOH (2 ml) was added and the resulting mixture was evaporated to dryness under reduced pressure. The residue was partitioned between EtOAc (5 ml) and 1% NaHCO3 (5 ml). The precipitate formed was filtered off, washed with H2O (5 ml), fresh EtOAc (5 ml) and dried to give the title compound (0.019 g; 61%) as creamy solid. 1H-NMR (DMSO-d6) 1.28-1.41 (m, 6H): 3.2-3.4 (m, 2H+H2O); 3.5-4.02 (m, 7H); 4.07-4.18 (m, 4H); 4.6 (broad s, 2H); 6.52 (d, 1H, J=6 Hz); 7.06-7.19 (m, 3H); 7.58 (d, 1H, J=3 Hz); 7.72 (dd, 1H, J=9 Hz).

Provenance & Evidence