HCID 86717828, compound → HCID 70872838, compound

Participants

Reaction Steps

To a stirred solution of 5-bromo-3-chloro-N-methoxy-N-methylthiophene-2-carboxamide (1 g, 3.5 mmol) in THF (10 mL) was added MeMgBr (1.1 mL, 3.5 mmol) under N2 at RT. The mixture was stirred at RT for 0.5 h and quenched by aqueous NH4Cl. The resulting solution was extracted with EtOAc. The organic layers were dried over Na2SO4, concentrated and purified by column to give 0.6 g of 1-(5-bromo-3-chlorothiophen-2-yl)ethanone. MS (M+H): 239, 241. 1H NMR (400 MHz, CDCl3): δ 6.95 (s, 1H), 2.57 (s, 3H).

Provenance & Evidence