1,1'-Carbonyldiimidazole → HCID 178484390, compound

Participants

Reaction Steps

The respective carboxylic acid (1 eq.) was dissolved in DMF (5 ml), treated with carbonyldiimidazole (1 eq.) and stirred at room temperature for 1 h. N-Hydroxy-benzimidazol-5-carboxamidine (1 eq.) was added and the mixture was heated to 110° C. over night. After cooling to room temperature, the mixture was diluted with water until a precipitate was formed, basified by means of sat. NaHCO3-solution and extracted with EtOAc (3×25 ml). The combined organic layers were dried over Na2SO4, evaporated and the residue was purified by flash chromatography on silica using a CHCl3/MeOH gradient.

Provenance & Evidence