Phosphorus oxychloride → HCID 178490024, compound

Participants

Reaction Steps

The compound was synthesized starting from benzimidazol-5-carbohydrazide (176 mg, 1 mmol), TEA (0.153 ml; 1.1 mmol), 2,4-dimethoxyphenylpropionylchloride (228 mg, 1.1 mmol) and POCl3 (0.5 ml; 5.5 mmol) as described in method 1; yield: 0.013 mg (3.7%); MS m/z: 351.3[M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 2.97-3.00 (m, 2H); 3.11-3.13 (m, 2H); 3.71 (s, 6H); 6.41-6.43 (m, 1H); 6.51 (br s, 1H); 7.06-7.08 (m, 1H); 7.75-7.77 (m, 1H); 7.81-7.83 (m, 1H); 8.15 (br s, 1H); 8.43 (s, 1H); HPLC (METHOD [A]): rt 12.06 min (100%)

Provenance & Evidence