1H-benzimidazole-5-carbohydrazide → HCID 178492804, compound

Participants

Reaction Steps

The compound was synthesized starting from benzimidazol-5-carbohydrazide (176 mg, 1 mmol) and 3,4-dimethoxyphenylsulfonylthioacetic acid (261 mg; 1 mmol) as described in method 2 but purified by flash chromatography on silica using a CHCl3/MeOH gradient; yield: 0.022 g (5.5%); MS m/z: 401.2 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 3.75 (s, 3H); 3.82 (s, 3H); 5.29 (s, 2H); 7.15 (d, 1H3J=8.7 Hz); 7.328-7.333 (m, 1H); 7.38 (dd, 1H, 4J=2.1 Hz, 3J=8.7 Hz); 7.68-7.72 (m, 1H); 7.78-7.82 (m, 1H); 8.01 (br s, 1H); 8.38 (s, 1H); 12.80 (br s, 1H); HPLC (METHOD [A]): rt 10.19 min (90.6%)

Provenance & Evidence