反应详情

The compound was synthesized starting from benzimidazol-5-carbohydrazide (176 mg; 1 mmol), TEA (0.153 ml; 1.1 mmol), 2,4-dimethoxyphenylpropionylchloride (228 mg, 1.1 mmol) and Lawesson's reagent (606 mg; 1.5 mmol) as described in method 1; yield: 0.022 g (6.0%); MS m/z: 367.2 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 2.94 (t, 2H, 3J=7.9 Hz); 3.30 (t, 2H, 3J=7.9 Hz); 3.70 (s, 3H); 3.74 (s, 3H); 6.41 (dd, 1H, 4J=2.5 Hz, 3J=8.3 Hz); 6.51 (d, 1H, 4J=2.5 Hz); 7.05 (d, 1H, 3J=8.3 Hz); 7.68 (d, 1H, 3J=8.7 Hz); 7.74 (dd, 1H, 4J=1.7 Hz, 3J=8.7 Hz); 8.09 (br s, 1H); 8.34 (s, 1H); HPLC (METHOD [A]): rt 12.63 min (97.6%)

1. customThe compound was synthesized
2. customrt 12.63 min (97.6%)