Dicyclohexylcarbodiimide → HCID 178490025, compound

Participants

Reaction Steps

The compound was synthesized starting from 3-(3-chloro-4-methoxyphenyl)propionic acid (215 mg; 1 mmol), DCC (206 mg; 1 mmol), benzimidazol-5-carbohydrazide (176 mg; 1 mmol) and Lawesson's reagent (606 mg; 1.5 mmol) as described in method 2; yield: 0.032 g (8.6%); MS m/z: 371.1/373.2 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 3.05 (t, 2H, 3J=7.5 Hz); 3.44 (t, 2H, 3J=7.5 Hz); 3.81 (s, 3H); 7.05 (d, 1H, 3J=8.7 Hz); 7.22 (dd, 1H, 4J=2.1 Hz, 3J=8.7 Hz); 7.39 (d, 1H, 4J=2.1 Hz); 7.83 (d, 1H, 3J=8.7 Hz); 7.92 (dd, 1H, 4J=1.7 Hz, 3J=8.7 Hz); 8.22 (d, 1H, 4J=1.7 Hz); 8.93 (s, 1H); HPLC (METHOD [A]): rt 13.65 min (98.9%)

Provenance & Evidence