Phosphorus oxychloride → HCID 178506155, compound

Participants

Reaction Steps

The compound was synthesized starting from 3-(4-trifluoromethylphenyl)propionic acid (219 mg; 1 mmol), benzimidazol-5-carbohydrazide (176 mg; 1 mmol), Lawesson's reagent (606 mg; 1.5 mmol) and POCl3 (0.137 ml; 1.5 mmol) as described in method 3; yield: 0.017 g (4.5%); MS m/z: 375.1 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 3.22 (t, 2H, 3J=7.5 Hz); 3.52 (t, 2H, 3J=7.5 Hz); 7.53-7.55 (m, 2H); 7.65-7.67 (m, 2H); 7.84 (d, 1H, 3J=8.7 Hz); 7.92 (dd, 1H, 4J=1.7 Hz, 3J=8.7 Hz); 8.22-8.23 (m, 1H); 8.93 (s, 1H); HPLC (METHOD [A]): rt 14.82 min (98.3%)

Provenance & Evidence