Phosphorus oxychloride → HCID 178506166, compound

Participants

Reaction Steps

The compound was synthesized starting from 3-(2,5-bis(trifluoromethyl)phenyl)propionic acid (287 mg; 1 mmol), benzimidazol-5-carbohydrazide (176 mg; 1 mmol), Lawesson's reagent (606 mg; 1.5 mmol) and POCl3 (0.137 ml; 1.5 mmol) as described in method 3; yield: 0.013 g (2.9%); MS m/z: 443.4 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 3.36-3.40 (m, 2H); 3.51-3.55 (m, 2H); 7.82-7.85 (m, 2H); 7.92 (dd, 1H, 4J=1.7 Hz, 3J=8.3 Hz); 7.97 (d, 1H, 3J=8.3 Hz); 8.06 (br s, 1H); 8.23-8.24 (m, 1H); 8.88 (s, 1H); HPLC (METHOD [A]): rt 16.42 min (96.7%)

Provenance & Evidence