Phosphorus oxychloride → HCID 178505670, compound

Participants

Reaction Steps

The compound was synthesized starting from 3-(2,4-difluorophenyl)propionic acid (187 mg; 1 mmol), benzimidazol-5-carbohydrazide (176 mg; 1 mmol), Lawesson's reagent (606 mg; 1.5 mmol) and POCl3 (0.137 ml; 1.5 mmol) as described in method 3; yield: 0.009 g (2.6%); MS m/z: 342.2 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 3.12 (t, 2H, 3J=7.5 Hz); 3.44 (t, 2H, 3J=7.5 Hz); 7.02-7.05 (m, 1H); 7.17-7.22 (m, 1H); 7.40-7.46 (m, 1H); 7.79 (d, 1H, 3J=8.7 Hz); 7.87 (dd, 1H, 4J=1.7 Hz, 3J=8.7 Hz); 8.19 (d, 1H, 4J=1.7 Hz); 8.72 (s, 1H); HPLC (METHOD [A]): rt 12.69 min (85.5%)

Provenance & Evidence