Phosphorus oxychloride → HCID 178505669, compound

Participants

Reaction Steps

The compound was synthesized starting from 3-(3,4-difluorophenyl)propionic acid (186 mg; 1 mmol), benzimidazol-5-carbohydrazide (176 mg; 1 mmol), Lawesson's reagent (606 mg; 1.5 mmol) and POCl3 (0.137 ml; 1.5 mmol) as described in method 3; yield: 0.02 g (5.8%); MS m/z: 343.3 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 3.11 (t, 2H, 3J=7.5 Hz); 3.47 (t, 2H, 3J=7.5 Hz); 6.97-6.99 (m, 1H); 7.32-7.35 (m, 1H); 7.40-7.46 (m, 1H); 7.82 (d, 1H, 3J=8.7 Hz); 7.91 (dd, 1H, 4J=1.7 Hz, 3J=8.7 Hz); 8.22 (d, 1H, 4J=1.7 Hz), 8.87 (s, 1H); HPLC (METHOD [A]): rt 13.09 min (85.7%)

Provenance & Evidence