Dicyclohexylcarbodiimide → HCID 178492570, compound

Participants

Reaction Steps

The compound was synthesized starting from 3-(2,5-dimethoxyphenyl)propionic acid (210 mg; 1 mmol), DCC (206 mg; 1 mmol), benzimidazol-5-carbohydrazide (176 mg; 1 mmol) and Lawesson's reagent (606 mg; 1.5 mmol) as described in method 2; yield: 0.04 g (10.9%); MS m/z: 367.3 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 3.03 (t, 2H, 3J=7.5 Hz); 3.38 (t, 2H, 3J=7.5 Hz); 3.66 (s, 3H); 3.73 (s, 3H); 6.76 (dd, 1H, 4J=2.9 Hz, 3J=9.1 Hz); 6.82 (d, 1H, 4J=2.9 Hz); 6.89 (d, 1H, 3J=9.1 Hz); 7.81 (d, 1H, 3J=8.7 Hz); 7.89 (dd, 1H, 4J=1.7 Hz, 3J=8.7 Hz); 8.21 (d, 1H, 4J=1.7 Hz); 8.82 (s, 1H); HPLC (METHOD [A]): rt 12.62 min (93.1%)

Provenance & Evidence