Phenoxyacetic Acid → HCID 178420517, compound

Participants

Reaction Steps

The compound was synthesized starting from phenoxyacetic acid (153 mg; 1 mmol), benzimidazol-5-carbohydrazide (176 mg; 1 mmol), Lawesson's reagent (606 mg; 1.5 mmol) and POCl3 (0.137 ml; 1.5 mmol) as described in method 3; yield: 0.031 g (10.1%); MS m/z: 309.0 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 5.64 (s, 2H); 6.99-7.03 (m, 1H); 7.09-7.12 (m, 2H); 7.32-7.36 (m, 2H); 7.84 (d, 1H, 3J=8.3 Hz); 7.98 (dd, 1H, 4J=1.7 Hz, 3J=8.3 Hz); 8.31 (d, 1H, 4J=1.7 Hz); 8.90 (s, 1H); HPLC (METHOD [A]): rt 12.07 min (95.9%)

Provenance & Evidence