Phosphorus oxychloride → HCID 178420565, compound

Participants

Reaction Steps

The compound was synthesized starting from (phenylthio)acetic acid (169 mg; 1 mmol), benzimidazol-5-carbohydrazide (176 mg; 1 mmol), Lawesson's reagent (606 mg; 1.5 mmol) and POCl3 (0.137 ml; 1.5 mmol) as described in method 3; yield: 0.019 g (5.9%); MS m/z: 325.7 [M+H]+; 1H-NMR (DMSO d6, 400 MHz): δ 4.77 (s, 2H); 7.21-7.25 (m, 1H); 7.31-7.35 (m, 2H); 7.43-7.45 (m, 2H); 7.79 (d, 1H, 3J=8.3 Hz); 7.89 (dd, 1H, 4J=1.7 Hz, 3J=8.3 Hz); 8.21 (br s, 1H); 8.83 (s, 1H); HPLC (METHOD [A]): rt 12.30 min (95.2%)

Provenance & Evidence