Water → HCID 86688544, compound

Participants

Reaction Conditions

Reaction Steps

Phenyl chloroformate (3.49 g, 22.3 mmol) was dissolved in acetonitrile (20 mL), and 2-amino-6-bromobenzothiazole (5.06 g, 22.1 mmol) dissolved in dimethylacetamide (20 mL) was added thereto, followed by stirring at 50° C. for 17 hours. The compound (5.51 g, 22.3 mmol) obtained in Example 1 (2) and triethylamine (hereinafter referred to as Et3N) (12.8 mL, 91.9 mmol) were added to the resulting mixture, followed by stirring at 70° C. for 5 hours. Water (120 mL) was added to the resulting mixture, and the precipitate was collected by filtration and washed with ethanol, thereby giving the title compound (5.84 g, 62%) as a brown solid.

Provenance & Evidence