HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → 4,5-Bis(4-methoxyphenyl)-1,3-oxazole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | Ethyl 4,5-bis(4-methoxyphenyl)-1,3-oxazole-2-carboxylate | HCID 69712984 | — |
| Product | 4,5-Bis(4-methoxyphenyl)-1,3-oxazole-2-carboxamide | HCID 69817925 | 71.9% |
Reaction Steps
In WO2004/065374 is disclosed a method in which ethyl 4,5-bis(4-methoxyphenyl)-1,3-oxazole-2-carboxylate, which is a carboxylic acid ester, is allowed to react with formamide in the presence of sodium methoxide, which is a metal alkoxide, to give 4,5-bis(4-methoxyphenyl)-1,3-oxazole-2-carboxamide, which is a carboxamide, in a yield of 71.9% (see Example 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822724B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-4d806f3c603144478d89c72646072c98 |
| Source note | uspto-grants-2014_09 |