Sodium Carbonate → HCID 86688547, compound

Participants

Reaction Steps

The compound (200 mg, 466 μmol) obtained in Example 1 and pyridine-4-boronic acid (115 mg, 932 μmol) were dissolved in a mixture of dimethoxyethane (4 mL) and DMF (2 mL), and a 2N sodium carbonate aqueous solution (700 μL, 1.40 mmol) and tetrakis(triphenylphosphine)palladium(0) (80 mg, 70 μmol) were added thereto. The resulting mixture was subjected to reaction at 120° C. for 20 minutes in a microwave reactor. A saturated ammonium chloride aqueous solution was added to the resulting mixture to stop the reaction, and the precipitate was collected by filtration. The residue was purified using medium pressure flash column chromatography (silica gel; methanol:chloroform=1:30), thereby giving the title compound (34 mg, 17%) as an amorphous solid.

Provenance & Evidence