Triphenylarsine → HCID 67378027, compound

Participants

Reaction Conditions

Reaction Steps

A tube was charged 3-(tributylstannyl)-7-(ethylamino)-1-methyl-1,6-naphthyridin-2(1H)-one (48 mg, 0.1 mmol), N,N-bis-BOC-3,5-difluoro-4-iodopyridin-2-amine (54 mg, 0.12 mmol), Ph3As (25 mg, 0.08 mmol), CuI (7.5 mg, 0.04 mmol) and Pd2(dba)3 (9 mg, 0.01 mmol). The tube was degassed and refilled with nitrogen gas. DMF (10 mL) was added, and then the tube was sealed and heated at 60° C. for 48 h. Aqueous sodium bicarbonate solution was added, and the mixture was extracted with ethyl acetate. The combined organic layers were washed with water and brine, dried over sodium sulfate, filtered, and concentrated. The residue was chromatographed on silica gel (70% ethyl acetate in hexanes eluant) to provide the title compound. MS (m/z) 533.2 (M+1).

Provenance & Evidence