反应详情

A solution of trametinib (500.0 mg) in dimethyl sulfoxide (2.5 mL) was heated from room temperature to 80° C. with stirring to dissolve. The solution was further stirred for 2 hours and then precipitation was observed. The suspension was stirred at 80° C. for another 3 hours and cooled to room temperature and then stirred over night. The precipitate was collected by filtration and dried under reduced pressure at 30° C. for 16 hours to give trametinib dimethyl sulfoxide solvate.

1. dissolutionto dissolve
2. stirringThe solution was further stirred for 2 hours
3. customprecipitation
4. stirringThe suspension was stirred at 80° C. for another 3 hours
5. stirringstirred over night
6. filtrationThe precipitate was collected by filtration
7. customdried under reduced pressure at 30° C. for 16 hours