HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → Trametinib Dimethyl Sulfoxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Trametinib | HCID 11707110 | — |
| Product | Trametinib Dimethyl Sulfoxide | HCID 50992434 | — |
Reaction Steps
A solution of trametinib (200.0 mg) in dimethyl sulfoxide (50.0 mL) was heated from room temperature to 80° C. The solution was concentrated under reduced pressure at 80° C. until the solvent dried up to give trametinib dimethyl sulfoxide solvate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09181243B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-7d1941735bcf4e4caac867dada878e65 |
| Source note | uspto-grants-2015_11 |