Dimethyl Sulfoxide → Trametinib Dimethyl Sulfoxide

Participants

Reaction Steps

Dimethyl sulfoxide (2 mL) was added to trametinib (80 mg) solids and the mixture was treated by ultrasound at 40 KHz for 5 minutes. The mixture suspension was stirred at room temperature for 7 days to crystallize and then centrifuged. The precipitate was collected and dried under reduced pressure at 40° C. for 16 hours to give trametinib dimethyl sulfoxide solvate Form M (75.8 mg, yield 84.1%).

Provenance & Evidence