反应详情

Dimethyl sulfoxide (1 mL) was added to trametinib (60 mg) at 40° C. under stirring to give a pale yellow solution. The solution was cooled with a rate of 2° C. per hour to 20° C., and then the mixture was stirred at 20° C. for 16 hours. The precipitate was collected and dried under reduced pressure at 40° C. for 24 hours to give trametinib dimethyl sulfoxide solvate Form M (58.4 mg, yield 86.4%).

1. customto give a pale yellow solution
2. temperatureThe solution was cooled with a rate of 2° C. per hour to 20° C.
3. stirringthe mixture was stirred at 20° C. for 16 hours
4. customThe precipitate was collected
5. customdried under reduced pressure at 40° C. for 24 hours